Xylazine

Prescription items are NON-RETURNABLE and NON REFUNDABLE Xylazine HCl Injection 20 mg/mL Indications Xylazine HCl Injection (xylazine) should be used in dogs and cats when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia. Xylazine HCl Injection (xylazine) has been used successfully as follows: 1. Diagnostic procedures-examination of mouth and ears, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations. 2. Orthopedic procedures, such as application of casting materials and splints. 3. Dental procedures. 4. Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations. 5. To calm and facilitate restraint of fractious animals. 6. Therapeutic medication for sedation and relief of pain following injury or surgery. 7. Major surgical procedures: a. When used as a preanesthetic to general anesthesia. b. When used in conjunction with local anesthetics. Xylazine HCl Injection 20 mg/mL Dosage And Administration 1. Dosage - Intravenously-0.5 mL/20 lbs. body weight (0.5 mg/lb.) Intramuscularly or Subcutaneously-1 mL/20 lbs. body weight (1 mg/lb.) In large dogs (over 50 lbs.), a dosage of 0.5 mg/lb. administered intramuscularly may provide sufficient sedation and/or analgesia for most procedures. Since vomiting may occur (see SIDE EFFECTS), fasting for 6-24 hours prior to the use of Xylazine HCl Injection (xylazine) may reduce the incidence; the I.V. route results in the least vomiting. Following injection of Xylazine HCl Injection (xylazine), the animal should be allowed to rest quietly until the full effect has been reached. These dosages produce sedation which is usually maintained for 1 to 2 hours and analgesia which lasts for 15 to 30 minutes. 2. Preanesthetic to Local Anesthesia - Xylazine HCl Injection (xylazine) at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine. 3. Preanesthetic to General Anesthesia - Xylazine HCl Injection (xylazine), at the recommended dosage rates, produces an additive effect to central nervous system depressants such as pentobarbital sodium, thiopental sodium and thiamylal sodium. Therefore, the dosage of such compounds should be reduced and administered to the desired effect. In general, 1/3 to 1/2 of the calculated dosage of the barbiturates will be needed to produce a surgical plane of anesthesia. Post-anesthetic or emergence excitement has not been observed in animals preanesthetized with Xylazine HCl Injection (xylazine). Xylazine HCl Injection (xylazine) has been used successfully as a preanesthetic agent for pentobarbital sodium, thiopental sodium, thiamylal sodium, nitrous oxide, ether, halothane and methoxyflurane anesthesia. Side Effects Emesis occurs occasionally in dogs, and frequently in cats, soon after the administration of Xylazine HCl Injection (xylazine), but before clinical sedation is evident. When observed, emesis usually occurs only a single time, after which there is no further emetic effect. The use of antiemetics may delay this phenomenon. The occurrence of emesis may be considered a desirable effect when Xylazine HCl Injection (xylazine) is administered as a preanesthetic to general anesthesia. Xylazine HCl Injection (xylazine) used at recommended dosage levels may occasionally cause slight muscle tremors, bradycardia with partial A-V heart block and a reduced respiratory rate. Should excessive respiratory depression occur following the use of Xylazine HCl Injection (xylazine), administer respiratory stimulants and provide artificial respiration. Movement in response to sharp auditory stimuli may be observed. Increased urination may occur in cats following the use of Xylazine HCl Injection (xylazine). Precautions Clinical results with xylazine have not revealed any detrimental effects when the compound is administered to pregnant dogs or cats. However, until more definitive studies are completed, Xylazine HCl Injection (xylazine) is not recommended for use in these animals. Careful consideration should be given before administering to dogs or cats with significantly depressed respiration, severe pathologic heart disease, advanced liver or kidney disease, severe endotoxic or traumatic shock and stress conditions such as extreme heat, cold, or fatigue. Analgesic effect is variable, and depth should be carefully assayed prior to surgical/clinical procedures. In spite of sedation, the practitioner and handlers should proceed with caution since defense reactions may not be diminished. Do not use Xylazine HCl Injection (xylazine) in conjunction with tranquilizers. Since an additive effect results from the use of Xylazine HCl Injection (xylazine) and the barbiturate compounds, it should be used with caution with these central nervous system depressants. Products known to produce respiratory depression or apnea, such as thiamylal sodium, should be given at a reduced dosage and, when injected intravenously, should be administered slowly. When intravenous administration is desired, avoid perivascular injection in order to achieve the desired effect. Studies have shown negligible evidence of tissue irritation, however, following perivascular injection of xylazine. Bradycardia and an arrhythmia in the form of incomplete atrioventricular block have been reported following xylazine administration. Although clinically the importance of this effect is questioned,1 a standard dose of atropine given prior to or following Xylazine HCl Injection (xylazine) will greatly decrease the incidence. While sedation usually lasts from 1 to 2 hours, recovery periods in excess of 4 to 5 hours have been reported in both dogs and cats. Safety Xylazine HCl Injection (xylazine) is tolerated in dogs and cats at 10 times the recommended dose. However, doses of this magnitude produce muscle tremors, emesis and long periods of sedation. Warning This drug is for use in dogs and cats only. « Read less

Prescription items are NON-RETURNABLE and NON REFUNDABLE Xylazine HCl Injection 20 mg/mL Indications Xylazine HCl Injection (xylazine) should be used in dogs and cats when it is desirable to produce a state of sedation accompanied by a shorter period ...Read more »

Prescription items are NON-RETURNABLE and NON REFUNDABLE Delaware, New Jersey, Ohio, Pennsylvania, and West Virginia require signature upon delivery. Xylazine HCl Injection 100 mg / ml 50 ml Vial Xylazine HCl Injection (xylazine) should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia. Horses: Xylazine HCl Injection (xylazine) has been used successfully as follows: 1.Diagnostic procedures-oral and ophthalmic examinations, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations. 2.Orthopedic procedures, such as application of casting materials and splints. 3.Dental procedures. 4.Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations. 5.To calm and facilitate handling of fractious animals. 6.Therapeutic medication for sedation and relief of pain following injury or surgery. 7.Major surgical procedures: a.When used as a preanesthetic to general anesthesia. b.When used in conjunction with local anesthetics. Cervidae: Xylazine HCl Injection (xylazine) may be used for the following: 1.To calm and facilitate handling of fractious animals. 2.Diagnostic procedures. 3 .Minor surgical procedures. 4.Therapeutic medication for sedation and relief of pain following injury or surgery. 5.As a preanesthetic to local anesthesia. Xylazine HCl Injection (xylazine) at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine. Ingredients: Each mL contains: 100 mg Xylazine, (base equivalent), 0.9 mg methylparaben, 0.1 mg propylparaben, water for injection; citric acid and sodium citrate for pH adjustment to 5.5 ± 0.3. Active Ingredients: Xylazine hydrochloride (Equivalent to 10% base) 11.4% Inert Ingredients: 88.6% 100.0% Possible Side Effects: Xylazine HCl Injection (xylazine) in horses and Cervidae, used at recommended dosage levels may occasionally cause slight muscle tremors, bradycardia with partial A-V heart block and a reduced respiratory rate. Movement in response to sharp auditory stimuli may be observed. In horses, sweating, rarely profuse, has been reported following administration. In Cervidae, salivation, various vocalizations (bellowing, bleating, groaning, grunting, snoring) on expiration, audible grinding of molar teeth, protruding tongue and elevated temperatures have also been noted in some cases. Precautions: Careful consideration should be given before administering to horses and Cervidae with significantly depressed respiration, severe pathologic heart disease, advanced liver or kidney disease, severe endotoxic or traumatic shock and stress conditions such as extreme heat, cold, high altitude or fatigue. Do not use Xylazine HCl Injection (xylazine) in conjunction with tranquilizers. Analgesic effect is variable, and depth should be carefully assayed prior to surgical/clinical procedures. Variability of analgesia occurs most frequently at the distal extremities of horses and Cervidae. In spite of sedation, the practitioner and handlers should proceed with caution since defense reactions may not be diminished. Horses: Since an additive effect results from the use of Xylazine HCl Injection (xylazine) and the barbiturate compounds, it should be used with caution with these central nervous system depressants. Products known to produce respiratory depression or apnea, such as thiamylal sodium, should be given at a reduced dosage and, when injected intravenously, should be administered slowly. When intravenous administration of Xylazine HCl Injection (xylazine) is desired, avoid perivascular injection in order to achieve the desired effect. Studies have shown negligible evidence of tissue irritation, however, following perivascular injection of xylazine. Intracarotid Arterial Injection Should Be Avoided. As with many compounds, including tranquilizers, immediate violent seizures followed by collapse may result from inadvertent administration into the carotid artery. Although the reaction with Xylazine HCl Injection (xylazine) is usually transient and recovery may be rapid and complete, special care should be taken to assure that the needle is in the jugular vein rather than the carotid artery. Bradycardia and arrhythmia in the form of incomplete atrioventricular block have been reported following xylazine administration. Although clinically the importance of this effect is questioned,1,2,3,4 a standard dose of atropine given prior to or following xylazine will greatly decrease the incidence. Sedation for transport is most successful if actual transportation is begun after the full effect of the drug has been reached and the animal's stability is maintained while standing. In addition, it should be noted that animals under the influence of xylazine can be aroused by noise or other stimuli and this may increase the risk of injury. Cervidae: As in all ruminants, it is preferable to administer Xylazine HCl Injection (xylazine) to fasted Cervidae as a safeguard against aspiration of food material into the lungs and/or bloat during deep sedation. Care should be taken to administer Xylazine HCl Injection (xylazine) in the heavy muscles of the croup or shoulder. Injections given subcutaneously, intraperitoneally or into fat deposits will give unpredictable results. Intra-arterial injection should be avoided, as with many compounds, including tranquilizers, immediate violent seizures followed by collapse may result from inadvertent administration into an artery. The animal should not be disturbed during induction or until the full effect of the drug has been reached which is usually 10 to 15 minutes following injection. The usual time to initial effect of the drug is 2 to 5 minutes. The administrator of the drug should be fully cognizant of this interval prior to administration of drug to free-ranging deer or elk, especially at night or in heavily wooded areas. If the animal has been underdosed (faulty injection or miscalculation on weight) it is advisable to wait one hour before administering a second dose. Adequate ventilation- especially in cages or crates- is mandatory; keep head and neck in position to insure patient air passage and to prevent aspiration of stomach contents. During sedation, animals should be prevented from assuming lateral recumbency. A sternal recumbent position is desirable. While under the effects of Xylazine HCl Injection (xylazine) the animal should be protected from extreme hot or cold environments. Efforts should be made to prevent patient from rising until almost complete recovery is attained. The transportation of Cervidae given Xylazine HCl Injection (xylazine) should be carefully monitored to prevent excessive struggling, injury or death. Hyperthermic reactions may occur, especially if the subject is in a highly excited state when the drug is administered. Hosing the head and entire body with cold water has usually proven to be an effective deterrent. The safety of Xylazine HCl Injection (xylazine) has not been demonstrated in pregnant Cervidae. Avoid use during the breeding season. Cervidae should be observed closely until all of the sedative effects of Xylazine HCl Injection (xylazine) are gone. Care should be taken at all times when administering Xylazine HCl Injection (xylazine) to Cervidae. This is due to the method of administration (usually darting), the difficulty in estimating body weights and the accepted theory that wild animals are more unpredictable in their response to sedatives and analgesics than the domesticated species. Dosage and Administration: Consult your veterinarian for proper dosage method and amount. Warning: This drug should not be administered to domestic food-producing animals. Not for use in horses intended for food. Avoid accidental administration to humans. Should such exposure occur « Read less

Prescription items are NON-RETURNABLE and NON REFUNDABLE Delaware, New Jersey, Ohio, Pennsylvania, and West Virginia require signature upon delivery. Xylazine HCl Injection 100 mg / ml 50 ml Vial Xylazine HCl Injection (xylazine) should be used in ho ...Read more »