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All the Latest Deals, News and More: > Flea & Tick Control > Spot On > Item # 405588

K9 Advantix II for Dogs 4-Month Supply

Regularly: $62.99
Today's savings: 25%

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In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.

Over 55lb


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.10 lb.


Product Summary:

K9 Advantix II Dog: 4-Month Supply

K9 Advantix II delivers pest protection through topical action. It protects against fleas (flea eggs and larvae), ticks, mosquitoes, biting flies, and lice. It combines imidacloprid and permethrin with insect growth regulator pyriproxyfen, which interferes with the hormone signaling of molting insects so that fleas in immature stages are unable to molt. K9 Advantix II is for monthly use on puppie as young as 7 weeks old and dogs. Do not use on cats.

  • Repels and kills ticks, fleas, and mosquitoes
  • Repels biting flies
  • Kills lice
  • Kills all life stages of fleas
  • Prevents development of fleas, flea eggs, and larvae
  • Kills fleas within 12 hours of initial application
  • Kills reinfesting fleas within 2 hours
  • Protects against ticks that may transmit organisms that can cause Lyme disease, Rocky Mountain spotted fever, Ehrlichiosis, and Anaplasmosis
  • Waterproof: continues to work after a bath or weekly swimming (for optimal results, use a non-detergent shampoo)
  • One application lasts for a month
  • Can be used on puppies as young as 7 weeks old
  • Easy-to-follow application instructions on the back of every package
Item Specifications:

4-10 lb.: Green
11-20 lb.: Teal
21-55 lb.: Red
Over 55 lb.: Blue

Includes four applicators

Apply the entire contents of the tube evenly to two to three spots on the top of the back from the shoulder to the base of the tail. Monthly application.

Length of Effectiveness:
Under normal conditions, the product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days. After flea control is attained, return to a monthly retreatment schedule.

8.80% Imidacloprid
44.00% Permethrin
0.44% Pyriproxyfen
46.76% other ingredients
Active ingredients work synergistically. The combination of imidacloprid with permethrin exerts a unique synergistic effect on the arthropod nervous system that is greater than either ingredient alone. Each compound acts on a different receptor area of the nerve cell:

  • Imidacloprid: (nicotinic receptors) irreversibly opens nicotinic receptors on postsynaptic neurons, resulting in constant neuromuscular stimulation, spastic paralysis, and death
  • Permethrin: (sodium channels) causes prolonged sodium ion exchange across neuronal membranes, resulting in constant nerve discharge followed by spastic paralysis and death
  • When both ingredients are combined, the neurotoxic stimulation is greater than that seen with either ingredient alone
Downloadable Resources
Comparison ChartK9 Advantix II vs Frontline Plus
MSDSK9 Advantix II
Style Item Number Model Number UPC
4-10lb 405588 001 5420348 724089203489
11-20lb 405588 002 5420372 724089203724
21-55lb 405588 003 5420399 724089203991
Over 55lb 405588 004 5420410 724089204103

Product Reviews by Customers

4.9 / 5.0
9 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
Works as advertised
Kills fleas quick but keep the dog out of chlorinated water seems to wash away product.
October 3, 2016
Guess it's workin .... No bugs on my baby's...
I like this product. It works great. Priced right. No side effects on my pups. 2 Pit Bulls & 1 Poosh... As long as they're healthy and happy, so is momma =))
August 8, 2016
Advantix II is perfect for fleas! It has no side effects so I can give it to my very sensitive Chow/Rottie. Very easy to apply. Shipping was fast and accurate!
June 2, 2016
Excellent is a very reliable website. I've always been satisfied with their service.
April 20, 2016
The first package did not show up at my door. After contacting customer service I had to wait a week longer to see if the shipment would still come, but was contacted by a DOG.COM associate on the date promised to see if I has received the shipment. Since I still had not received the shipment, they sent another shipment at no cost to me. I did receive the second shipment in a timely manner.
November 8, 2015
Good protection for my dog
Advantix is easy to apply and protects my dog while we're in the park.
July 28, 2015
The purchase was at a good price. Arrived to my home quickly. Was easy to make the purchase.
September 8, 2014
Good Product
I have used this product for years, my vet. Recommended it to me. Works great!
June 26, 2014
Great for my babies!
it does NOT cause them to go into seizures like the rest of them do
April 16, 2014
Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 2 questions Browse 2 questions and 51 answers
Why did you choose this? Store
have used before and works well
Gail N on Oct 3, 2018
I use this size as a 1 month supply for 4 dogs. Seems to be the most effective flea solution available.
Bill F on Aug 16, 2018
have used before and works well
Gail N on Oct 3, 2018
I have never used any other flea/tick medication but K9 Advantix II and I have NEVER had any problem with fleas or ticks! And I am talking about living in the hot, humid environments of South Texas and South Florida where it is flea and tick season all year long!
Janice B on Aug 31, 2018
I use this size as a 1 month supply for 4 dogs. Seems to be the most effective flea solution available.
Bill F on Aug 16, 2018
because it works well for my dog better than Frontline
Sandra M on Jul 22, 2018
Tamara M on Jul 16, 2018
This is what my vet gives her
Jody F on Jun 10, 2018
Have used before seems to work
Beverly M on May 14, 2018
It's summer and we have ticks
Lynn P on May 11, 2018
Works great for my dog.
Shawn B on Feb 19, 2018
I use this product because I do not ever have trouble with fleas when I do. We live in the hot and humid southern part of Texas, so fleas can be a constant bother, even in the winter. I keep this on my dogs year-round and apply it every 4 to 5 weeks. It works like a charm. It is a little pricey, but so is fumigating your house to get rid of fleas!
Janice B on Feb 8, 2018
dan k on Dec 26, 2017
Product works great for my area. Living in the mountain region, ticks and mosquitoes are a factor. I want my dogs protected at all costs. I have very large dogs, so I can only attest to the large (over 55 lb) size. Have tried other products without success. This remains my go to for tick and mosquito protection..
Rebecca W on Aug 10, 2017
dogs need it
Dori M on Aug 9, 2017
It works well on my dogs
Nancy H on Jul 24, 2017
I have several German Shepherds and its the item that works the best for them.
Phyllis S on Jul 22, 2017
It's what works on my dog and the price is good.
CHERYL P on Jul 10, 2017
best flea and tick drops
Derrick W on Apr 29, 2017
Controls both fleas and ticks. Works well on my dog.
Christina S on Jan 6, 2017
Dara v on Dec 5, 2016
It's a good brand.
Royce S on Aug 25, 2016
Because it's the only brand that kills 100% of the fleas!
Glenda K on Jul 29, 2016
Best Flea and Tick treament
TARYN M on Jun 28, 2016
what our vet recommends
Amy S on Jun 25, 2016
Quality of product and pricing.
Sandra R on Jun 20, 2016
Recommended by vet
Leslie A on May 27, 2016
It kills fleas, ticks & mosquitoes.
karen g on May 26, 2016
It repels mosquitos and kills the fleas and their eggs and kills the mite. I've been using this for 2 yrs. now and found it works better than Frontline and advantex.
Marvin C on May 25, 2016
we have used this product every year, we have good results. One 95lb boxer and a 98lb shepherd mix. Momma's fur babies
ELIZABETH D on May 24, 2016
great product protects my dog all summer
athena p on May 11, 2016
The only one you offer, I needed them, reviews looked good, thought I would give it a try.
Denise F on Apr 26, 2016
I have found this to be the best product for ticks, so far. I have two dogs and order fairly frequently.
JANE C on Apr 5, 2016
two dogs.
Patrick K on Mar 1, 2016
I have two dogs in this weight range and this will treat them for 6 months
RENA B on Feb 10, 2016
noreen v on Jan 6, 2016
Works great on my GSD
Jaime B on Nov 30, 2015
Great stuff!!
DARLENE L on Nov 12, 2015
Frontline stoped working & my dog keeps getting fleas :(
Helene S on Nov 2, 2015
works great keeps fleas and mosquitoes off your dog.
Linda S on Oct 21, 2015
I like this product because it provides protection against fleas, ticks and mosquitos.
WENDY Z on Sep 11, 2015
I have always used K9 Advantix on my dogs and have never had any trouble with fleas or any other parasites -- even in the hot, humid climates of South Texas and Florida!
Janice B on Aug 31, 2015
I have been using this on my dogs for several years, and its effectiveness has not decreased as has been the case with other flea, tick and heartworm preventatives. Your prices are the best I could find.
Judy K on Jul 19, 2015
because I need it and it works.
Charlene I on Jun 21, 2015
This is the only product that has eliminated flea and mosquito problems for my dogs.
Pamela A on May 14, 2015
I have 6 small dogs in the house, this is the only flea product I have found that works.
debbie r on May 13, 2015
Excellent price and good reviews.
Darla J on May 13, 2015
Spring has finally sprung and so will the fleas, ticks and mosquitos that's why I chose what protects my little Luna the best. It has proven to be the ONLY effective medication to prevent critters on my little dog.
Teresa G on Apr 3, 2015
It works!
KATHY M on Mar 23, 2015
best price and it is only spot on that works for me.
MARIE G on Mar 13, 2015
I like it
Debra S on Feb 23, 2015
because it works in Fl. where its hard to control fleas etc.
RICHARD K on Jan 2, 2015
I have never used any other flea/tick medication but K9 Advantix II and I have NEVER had any problem with fleas or ticks! And I am talking about living in the hot, humid environments of South Texas and South Florida where it is flea and tick season all year long!
Janice B on Aug 31, 2018
because it works well for my dog better than Frontline
Sandra M on Jul 22, 2018
How many come in one box?
T. B. on Mar 4, 2018
BEST ANSWER: This item is a 4 month supply.