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K9 Advantix II for Dogs 12-Month Supply

Regularly: $174.99
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In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.

Over 55lb


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.40 lb.


Product Summary:

K9 Advantix II Dog: 12-Month Supply

K9 Advantix II delivers pest protection through topical action. It protects against fleas (flea eggs and larvae), ticks, mosquitoes, biting flies, and lice. It combines imidacloprid and permethrin with insect growth regulator pyriproxyfen, which interferes with the hormone signaling of molting insects so that fleas in immature stages are unable to molt. K9 Advantix II is for monthly use on puppies (as young as 7 weeks old) and dogs. Do not use on cats.

  • Repels and kills ticks, fleas, and mosquitoes
  • Repels biting flies
  • Kills lice
  • Kills all life stages of fleas
  • Prevents development of fleas, flea eggs, and larvae
  • Kills fleas within 12 hours of initial application
  • Kills reinfesting fleas within two hours
  • Protects against ticks that may transmit organisms that can cause Lyme disease, Rocky Mountain spotted fever, Ehrlichiosis, Anaplasmosis
  • Waterproof; continues to work after a bath or weekly swimming (for optimal results, use a non-detergent shampoo)
  • One application lasts for a month
  • Can be used on puppies as young as 7 weeks old
  • Easy-to-follow application instructions on the back of every package
Item Specifications:

4-10 lb.: Green
11-20 lb.: Teal
21-55 lb.: Red
Over 55 lb.: Blue

Includes 12 applicators

Apply entire contents of tube evenly to two to three spots on the top of the back from the shoulder to the base of the tail. Monthly application.

Length of Effectiveness:
Under normal conditions, the product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly retreatment schedule.

8.80% Imidacloprid
44.00% Permethrin
0.44% Pyriproxyfen
46.76% other ingredients
Active ingredients work synergistically. The combination of imidacloprid with permethrin exerts a unique synergistic effect on the arthropod nervous system that is greater than either ingredient alone. Each compound acts on a different receptor area of the nerve cell.
Imidacloprid (nicotinic receptors) irreversibly opens nicotinic receptors on postsynaptic neurons, resulting in constant neuromuscular stimulation, spastic paralysis, and death.
Permethrin (sodium channels) causes prolonged sodium ion exchange across neuronal membranes, resulting in constant nerve discharge followed by spastic paralysis and death.
When both ingredients are combined, the neurotoxic stimulation is greater than that seen with either ingredient alone.

Style Item Number Model Number UPC
4-10lb 405851 001 724089203649
11-20lb 405851 002 724089203809
21-55lb 405851 003 724089204028
Over 55lb 405851 004 724089204295

Product Reviews by Customers

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Browse 1 question Browse 1 question and 30 answers
Why did you choose this? Store
It kills fleas and ticks.
Jean M on Apr 1, 2019
Works well
DENISE P on Jul 5, 2018
It kills fleas and ticks.
Jean M on Apr 1, 2019
My vet recommends this over Frontline, and it is less expensive, so an easy choice.
JIM T on Aug 7, 2018
Works well
DENISE P on Jul 5, 2018
This have been using this though out the summer and it works great.
Dena B on May 28, 2018
This is the only product that I have found that works the best on my 2 dogs.
Victor S on Jul 11, 2017
It Works Will On My Dogs
Royce G on Jun 14, 2017
for my dog
Kevin D on Jun 5, 2017
for my dog ...!
Arthur R on Jun 3, 2017
Amy R on May 11, 2017
Want to protect my dogs from fleas and ticks.
terri P on May 2, 2017
for my dog..!
Kyle S on Apr 24, 2017
This works very well on both my dogs.
Sherry O on Mar 31, 2017
excellent control of fleas
MICHELE R on Mar 13, 2017
It works
Jeanne S on May 22, 2016
This stuff seems to work and the dogs don't seem to mind it.
William I on Apr 26, 2016
I had to switch from Advantage II because I moved to where there are a lot of ticks in the woods.
Diane H on Apr 5, 2016
I have 2 dogs in this weight range. this will give them protection for 6 months. My Female is allergic to bites, so it is important to have a repellent not one that protects after the bite.
RENA B on Feb 10, 2016
this is the brand I have used for years on my German Shepherds
Carmella L on Feb 3, 2016
I have 3 large dogs and i was out and i heard great things about his store!
Jose S on Nov 20, 2015
I was using other flea and tick medication that didn't work well. K9 Advantix 2 works the best with my dog.
GERALD F on Nov 4, 2015
Vet recommends
Linda G on Oct 21, 2015
only one that seems to work
margaret w on Oct 25, 2014
Other products cause a rash on my dog. Advantix seems to have the best quality available
HEIDI A on Oct 14, 2014
Doesnt have weight limit so only need one does for my mastiffs.
JENNIFER B on Oct 10, 2014
Great product!!!! Works flawlessly...never had a problem with either ticks or fleas while friends and neighbors complain what a bad season it is. I always have and always will recommend this product until there is something better. My only complaint is the price but, this is the least expensive place to purchase I've found.
CAROL C on Jul 19, 2014
Recommended by veterinarian. Best price I've found is on!
Erica S on Jul 1, 2014
I would never be without this.
Deni Y on Jun 14, 2014
its the best
cheryl b on Jun 9, 2014
I did not order 12 month supply over I order for 11 to 20lbs supply for my Pugs.I choose this item for the good price and because I need it in order to take care my dogs.
SYLVIA C on Apr 30, 2014
advantix works the best out of the products i have used
JUDITH W on Apr 1, 2014
My vet recommends this over Frontline, and it is less expensive, so an easy choice.
JIM T on Aug 7, 2018
This have been using this though out the summer and it works great.
Dena B on May 28, 2018