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Frontline Plus for Dogs - 6 Month Supply

Regularly: $106.89
Today's savings: 35%

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In Stock. Usually Ships within 24 hours.

23-44 Lbs.


In Stock. Usually Ships within 24 hours.

45-88 Lbs.


In Stock. Usually Ships within 24 hours.

89-132 Lbs


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.12 lb.


Product Summary:

FRONTLINE Plus for Dogs 6-Month Supply

Freeze! FRONTLINE® Plus stops disease-carrying fleas, ticks, and chewing lice in their tracks. It paralyzes the nervous system of these pests, effectively killing them, and prevents the development of flea eggs and larvae. This waterproof formula stays strong even after swimming, bathing, or playing in the rain. One easy, monthly application of FRONTLINE® Plus keeps itching at bay. Available in four sizes; select according to your dog’s weight. Consult your vet before using.


  • Effectively kills fleas, flea eggs, ticks, and chewing lice
  • Reduces the risk of parasite-transmitted infectious disease
  • Fast and easy dermal application
  • Only one application a month necessary
  • Safe for puppies eight weeks or older and dogs of all sizes
  • Approved for breeding, pregnant, and lactating dogs
  • Waterproof
  • 6-month supply
Item Specifications:

6-month supply

For dogs weighing:
5-22 lb.
23-44 lb.
45-88 lb.
89-132 lb.

Active Ingredients:
Fipronil 9.8%
S-methoprene 8.8%

Also available in 3-month supply (item #150929).

Style Item Number Model Number UPC
5-22lbs. 150930 2S P004FLTSP6-11-22 350604288008
23-44 Lbs. 150930 3M P004FLTSP6-23-44 350604288107
45-88 Lbs. 150930 4L P004FLTSP6-45-88 350604288206
89-132 Lbs 150930 5LX P004FLTSP6-89-132 350604288305

Product Reviews by Customers

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Browse 9 questions Browse 9 questions and 69 answers
Why did you choose this? Store
This is the product that we have used for years and love how well it works and ease of use. The big reason was that it saved us 30.00 compared to the vets charge for the same thing thank you so much
DOTTY L on Mar 27, 2019
I have used it in the past. Easy to apply & it works well.
Jack F on Jan 4, 2019
This is the product that we have used for years and love how well it works and ease of use. The big reason was that it saved us 30.00 compared to the vets charge for the same thing thank you so much
DOTTY L on Mar 27, 2019
works great
edward g on Mar 7, 2019
I have used it in the past. Easy to apply & it works well.
Jack F on Jan 4, 2019
It woks good
edward g on Nov 23, 2018
It works
Craig H on Nov 20, 2018
It covers mosquito's
SHARON L on May 10, 2018
We've purchased this product before & it works, & we like it for our dog.
Jack F on Mar 19, 2018
We've been using Frontline ever since we first noticed ticks in our rural area, and have never had a tick on any of our dogs.
Theresa K on Mar 3, 2018
Frontline Plus works very well for our dogs. We have tried other brands, but our dogs had bad reactions to those medications.
GARY M on Feb 19, 2018
Frontline is great and this is a good pricel
Chales D on Oct 4, 2017
recommended by my Vet and I have used the product for many years
herbert d on Sep 10, 2017
BILL W on Jul 11, 2017
only flea and tick killer that works for me
Pamela R on Jul 9, 2017
works use all the time have 6 dogs
Thelma E on Jun 18, 2017
doesn't irritate my dogs' skin nor make them itch!
LOIS W on May 12, 2017
It's a good value and works well for my Labs
Theresa K on Apr 16, 2017
Still recommended by veterinarian even with all the new products on the market.
tauna d on Apr 12, 2017
it works!
ANNE M F on Mar 29, 2017
It works effectively for my Border Collies.
Ann W on Feb 14, 2017
long time user
Eric B on Nov 27, 2016
I've used it and it works well.
Kit T on Nov 24, 2016
This is a product that we have used before & likes for our dog.
Jack F on Sep 25, 2016
Have used this product since it came out. Works great and doesn't bother any of our smaller breed dogs!
Bonnie L on Aug 18, 2016
Have used on all dogs for the last 15 years and never have had a flea or tick issue.
David R on Jul 26, 2016
SAFE FOR ALL DOGS! older product with great record, and I like some of the other products out there but have questions about there safty record
CAROL M on Jul 11, 2016
It works
CAROLYN R on Jun 24, 2016
I've tried other brands to control fleas and ticks, but only Frontline works consistently for my dogs.
James B on May 5, 2016
We use Frontline Plus for all of our digs and it's very effective!
LORETTA B on Apr 30, 2016
works really well..... I live in the country surrounded by grass trees and critters. My 7 dogs stay almost pest free with frontline plus.
LINDA G on Apr 8, 2016
necessary and cheaper
dorothea n on Mar 17, 2016
I have been using FrontLine since my Golden was a pup! Its never let me down! I have not found one flea on him and he's 12 years old. Fantastic reliable product.
Crystal F on Feb 29, 2016
Have had good results before
Charles F on Feb 27, 2016
I found that this worksthe best on my dogs
Barbara L on Feb 4, 2016
I have been using it for years and it works.
MARY ANNE C on Aug 25, 2015
Flea control
Susanna S on Aug 23, 2015
works better than any other product we have used
dave P on Aug 18, 2015
It has worked well for me in the past.
CHARLES R on Aug 10, 2015
I save a lot of money buying the large size. I apply the correct dosage needed per my 5 dogs. Doing it this way allows me 1 box 6 mo. purchase, protecting all my dogs from ticks.
(we do not have fleas in our area)
CINDY P on Jul 18, 2015
Always works, never any fleas, no side effects on dogs, used for many years and trust the product. Worth buying to keep dogs and home flea free.
Diane B on Jul 13, 2015
Price service convinience
luis a on Apr 27, 2015
Chose this because it's the only thing that works for my dog.
Kelly L P on Apr 25, 2015
excellent product
Richard J on Apr 8, 2015
it works !
diane p on Apr 6, 2015
I have used this product since the early 90's and have not found any other product as good or as reliable. It is expensive but I know my 2 rescued dogs are going to be protected from fleas and ticks.
DORALEE B on Mar 30, 2015
The product has been effective and does not irritate my poodles' skin.
JEFF H on Mar 18, 2015
Because the vets use it on the dogs.
JUDY W on Mar 16, 2015
Was going to get a small dog, however, didn't. Gave this to the Humane Society.
DEANNA M on Mar 1, 2015
Ticks are common in the area we live. Frontline has proven our dogs to be tick free.
MARY C on Feb 16, 2015
to protect my dog
EDWIN S on Dec 31, 2014
Recommended by my sister, Lisa. She has pets and advised me FrontLine was better than other brands.
Jane Y on Dec 4, 2014
works great
edward g on Mar 7, 2019
It woks good
edward g on Nov 23, 2018
Do I need a veterinarian prescription to buy Frontline plus here?
Chris on Mar 31, 2016
BEST ANSWER: No prescription needed, ever. Just order as much as you need and cheaper than the vet or any pet pharmacy.
Is this liquid or pill form?
A shopper on May 19, 2017
BEST ANSWER: It's a liquid in in individual flat, plastic vials. There's a narrow end that you snap, then part the dog's fir behind the neck (so it cannot lick the stuff off) and squirt onto skin. Very simple.
my dog is 21.5 lbs and is 3 years old. Should I buy the up to 22 lb frontline or the 23 - 44 ilb frontline?
Marsha P on Nov 17, 2014
BEST ANSWER: I'd feel comfortable going to the larger size (I have a 45 pound and a 95 pound dog, and I give them each the 50-100 pound meds). You may want to check with your vet, to confirm.
my dog weighs 165 pounds, will this protect him?
Jeff R on Jun 21, 2016
BEST ANSWER: I would suggest that you use 2 of the 46-88 pound size at a time. My friend has English Mastiffs and she has to use two of the large ones on them. You want to use what would go over the lbs. of your dog. Two of the 46 - 88 lbs. should cover up to 176 lbs and you want the dosage to be a little higher than your dog weighs. Watch your dog carefully to be sure it does not have a reaction, as sometimes you have to switch to Advantage of they have skin irritation from Frontline, or vice versa. You can confirm this with your vet if you have questions.
I just moved to an area that apparently has fleas in the warmer months. How is this applied and do you apply all year? I moved to this area mid October, 2016 and it is now 3/8/17 and haven't seen one flea yet.
George S on Mar 9, 2017
BEST ANSWER: I apply the frontline by spreading the dogs fur and squeezing on the skin around the area between the shoulders on their backs. My best success has been to start the frontline in the spring before the fleas start getting bad outdoors. It prevents the dogs from getting an infestation. I usually apply it all warm months till it starts to cool off and the fleas are killed by the cold weather outside.
Do you have larger quantities available?
Betty D on Oct 3, 2017
BEST ANSWER: We do sell this in a 12 month supply.
how many doses in order of Frontline for dogs up t 22 #?
A shopper on Jan 2, 2017
BEST ANSWER: The Frontline is available in 3 month and 6 month supplies for dogs under 22 lbs.
Hoe do I cancel this order?...
PATRICIA W on Sep 3, 2014