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Advantage II for Dogs 6-Month Supply

Regularly: $86.99
Today's savings: 28%

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In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.

Over 55lb


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.20 lb.


Product Summary:

Advantage II Dog: 6-Month Supply

This once-a-month topical treatment for fleas and lice on dogs and puppies seven weeks and older features a new formula with insect growth regulatory (IGR) to kill all life stages of fleas and contains Imidacloprid, which acts to disable a flea’s nervous system.


  • Kills all flea life stages, preventing fleas on treated pets from infesting your home
  • Kills adult fleas already on a pet within 12 hours, and re-infesting fleas within two hours
  • Waterproof
  • Fast and easy dermal application
  • Only one application a month necessary
  • Safe for puppies (7 weeks old) and dogs
Item Specifications:

Apply entire contents of tube on the dog's back between the shoulder blades. Apply monthly.

Length of Effectiveness:
Under normal conditions, product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly retreatment schedule.

Active Ingredients:
9.1% Imidacloprid
0.46% Pyripoxyfen
90.44% other ingredients

3-10 lb. – Green
11-20 lb. – Teal
21-55 lb. – Red
Over 55 lb. – Blue
Downloadable Resources
ChartAdvantage II
MSDSAdvantage II
Style Item Number Model Number UPC
3-10lb 405591 001 5420259 724089202598
11-20lb 405591 002 5420275 724089202758
21-55lb 405591 003 5420291 724089202918
Over 55lb 405591 004 5420321 724089203212

Product Reviews by Customers

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Browse 4 questions Browse 4 questions and 54 answers
Why did you choose this? Store
Good product works well........
Patty S on May 16, 2019
Frontline wasn't working, so we did a bit of research and this seems to be a viable option. We'll see!!
Julia M on Aug 4, 2018
Good product works well........
Patty S on May 16, 2019
Been using Advantage since it came out, love this product
Lynn S on Mar 13, 2019
Frontline wasn't working, so we did a bit of research and this seems to be a viable option. We'll see!!
Julia M on Aug 4, 2018
Because it keeps the fleas away
Kelley A on Jul 18, 2018
it works
VIRGINIA L on Jul 11, 2018
This is the only brand that has worked for the last two years on my pets.
Amanda J on Jun 5, 2018
used it before and it works well
Christine L on Nov 6, 2017
great price on flea stuff!!
Kevin O on Aug 20, 2017
Trying this vs. Frontline to see if it works as well.
Beth S on Aug 15, 2017
Works well
Gloria B on Aug 14, 2017
I have consistently had good luck with this product with tick control.
JANE C on Aug 13, 2017
Has worked well and is an okay price.
Barbara P on May 8, 2017
It works great, waterproof and very reliable, it is always working even when you can't see it.
Twila K on Apr 23, 2017
I have been using Advantage since it came out. Very good product.
Lynn S on Dec 27, 2016
Best topical Flea treatment. Ingestible treatment killed our dog.
JACQUELINE E on Dec 8, 2016
Have used this for years and have had no problems
LAWRENCE L on Jul 26, 2016
It's the only product that works well and it's cost efficient on this site.
Cecelia R on Jul 15, 2016
I have tried several products, and advantix always works the best with my dogs.
Karin E on Jul 13, 2016
It works the best for my dobie, no side effects & long lasting
Evelyn K on Jul 6, 2016
it is amazing! Worked as soon as I put it on my dogs.
judith K on Jul 1, 2016
To protect my dog from fleas.
Chris I on Jun 10, 2016
Ordered wrong product & returned Advantage for THE BEST stuff: Advantix. 50+ years with dogs & can't go wrong w/ Advantix. Works on everything unlike Advantage, Frontline, etc.
DEBORAH M. L on May 14, 2016
vet recommended
Steven R on May 14, 2016
I have had good experience with advantage II in the past
Jan J on May 3, 2016
Have been using Advantix II and recently began having issues with ticks. Time to try something else.
NELSON R on Apr 9, 2016
This product always works. We are rural with lots of woods. Never a flea or tick.
IRIS B on Feb 29, 2016
works good
MARIANNE W on Feb 23, 2016
works good and keeps misquetoes away
amy s on Jan 13, 2016
It has worked for my animals!
Ruby H on Dec 1, 2015
Only flea and tick preventative that I've found that has worked and also actually repels mosquitos. Only hold up is that it takes about a full day to dry into dog's skin.
Tyler R on Nov 29, 2015
only flea drops that work in my area
robin j on Nov 5, 2015
I chose this product because I like my dogs to be protected from those pesky fleas!
Coby M on Oct 14, 2015
This item works well, right price and free shipping Nice to do business with you
Charles K on Sep 23, 2015
It works
Gloria B on Sep 1, 2015
We've used this product for years so I don't really look at any other brands.
Nancy S on Jul 19, 2015
I have used Advantage II with great success. It is so much better than its competitors that I haven't even tried the others for years - no need to waste money when you are using the best product!.
LOUISE P on Jul 16, 2015
Works great! Have 2 dogs.
charlene c on Jun 9, 2015
I have been getting this product for years because this is the only one that protects my dogs against mosititoes also.
Kim S on May 12, 2015
This product works and the pricing is good!
JACK W on Apr 7, 2015
Trustworthy and not caustic.
SARA S on Mar 14, 2015
because it is a great flee control been using for ever.
polly t on Feb 1, 2015
The veterinarian told me this was least toxic for puppies.
Margaret S on Jan 2, 2015
excellent product,great price
GAIL A on Oct 6, 2014
This product has been very effective on my dogs.
JANE C on Jun 20, 2014
Good product
SCOTT M on May 30, 2014
Gail B on May 19, 2014
Flees on my dog
KIM J on Apr 18, 2014
Works great. By the 55 lb # for my Boxer and measure out proper amount for the smaller dogs (per vet's instructions)
Patricia A. H on Apr 13, 2014
because it works
RICHARD K on Mar 19, 2014
Been using Advantage since it came out, love this product
Lynn S on Mar 13, 2019
Because it keeps the fleas away
Kelley A on Jul 18, 2018
is Advantage made in the USA?
sheila g on Jan 29, 2015
BEST ANSWER: Don't know about Advantage. I highly recommend K9 Advantix II made by Bayer Healthcare, Kansas USA. Advantix does it all. Never had any problems in 30+ years.
Does Advantage II work on ticks?
A shopper on Jun 21, 2016
BEST ANSWER: Have not had ticks on our two large dogs, but we live in a semi desert area of CA., without any nearby woods. They are outside daily in both yards, with fruit trees. Do trust this flea product, but again, do not live in an area with deer ticks, etc.
A shopper on Apr 13, 2016
BEST ANSWER: Yes, but you need to wait approx. 48 hours after a bath to apply.